Systematic Review : Toxicity Allium cepa L. as an antioxidant by in vivo administration

Abstract

Background: Allium cepa L. has the potential to be developed into a traditional medicine in treating or preventing
chronic diseases to cancer. To ensure the safety of the use of Allium cepa L. as a traditional medicine, a toxicity
test is required. Based on this, it is necessary to carry out a systematic review of the toxicity test of Allium cepa
Objective: determine the therapeutic index and category of potential toxicity of Allium cepa L based on the LD50
value.
Method: This systematic review is carried out using research methods that summarize the results of primary
research to present more comprehensive facts and report research results from several research journals. This
review was made by tracing Problem, intervention, comparison and outcome. This search uses an electronic search
by referring to various sources. The journal used is a full text journal, in the form of an abstract accompanied by
the value of LD50 tocxicity.
Result: The LD50 value of the ethanol extract was 3000 mg/kg, ethanol extract (80%) was 400 mg/kg, and ethanol
extract (95%) was 39715 mg/kg. the average LD50 value of Allium cepa L 14371 mg/kgBW is included in the
practically non-toxic category and has a broad therapeutic index
Conclusion: The use of Allium cepa L. as a herbal medicine does not have the potential for toxicity, so it is safe
to use in the long term
Keywords: Antioxidant, lethal dose, Allium cepa, safety